Title:
Testing changes in craving and dopamine in abstinent smokers
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| What is the purpose of the study? |
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The aim of this study is to understand the changes in a brain receptor during abstinence. To do this, participants will be asked to abstain from smoking for up to 5 weeks. During this time, participants will undergo a PET scan, which estimates the level of the brain receptor we are interested in. These PET scans will occur at 1 week and at 5 weeks of abstinence. We will also collect information on craving and withdrawal symptoms to explore how these change over time during abstinence.
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| Who is needed? |
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Individuals with: |
regular smoker, healthy, smoker, nicotine dependent |
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Individuals without
a mental health or
addiction problem:
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Yes
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Age range: |
over age 19 |
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Gender: |
All |
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Ethnicity: |
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Other:
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| What does the study involve? |
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Number of contacts: |
1 phone pre-screen, 1 in-person eligibility screen, 3 PET scans, 1 MRI scan, 20 abstinence checks |
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Time period: |
13 weeks |
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Length of contacts: |
20 min phone call, up to 4 hour screen and scan sessions, 20 min abstinence checks |
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Treatment offered:
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No
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Location:
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250 College St.33 Russell St.
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Principal Investigator:
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Bernard Le Foll
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| Contact information: |
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Phone: |
416-535-8501 ext. 31536 |
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e-mail: |
Cigarettes.pet@camh.ca |
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Website: |
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Flyer:
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Study end date:
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31 Dec 2020
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| REB number: |
050/2018 |
| Full study title: |
Time-dependent changes in craving and dopamine in abstinent smokers: A [11C]-(+)-PHNO study |
| Keywords: |
smoking, smoker, PET, brain imaging, nicotine |
| Study Area: |
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